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PerkinElmer

CNS Research

OF

CNS research seeks to advance treatment for central nervous system disorders through the discovery and quantitation of biomarkers, mechanisms, and drug targets. Our broad range of CNS products meets all the needs of in vitro, in situ, and in vivo central nervous system research.

We offer biomarker detection kits with AlphaLISA? and LANCE? TR-FRET technology, cellular and in vivo imaging systems, and tissue pathology solutions to assess mechanisms of CNS disease in biochemical, cellular, tissue, and animal models. We also provide target-specific radiochemicals, radioligands, and receptor-transfected cell lines and cell membranes.

Applications for our CNS products include:

  • Measuring biomarkers of CNS disease in cells, brain tissue homogenates, cerebrospinal fluid, and other sample types with our fast, pre-validated kits
  • Studying targeted binding using our radiolabeled ligands and steroids
  • Quantitating biomarkers in tissue samples with our industry-leading immunohistochemistry products
  • CNS research in animal models from molecular, functional, and anatomical perspectives with our in vivo imaging systems
  • Performing phenotypic analysis with our high content screening solutions

Our CNS products are also well suited for CNS research in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Gain precise insight on disease biomarkers like phospho-tau, Ab42/Ab40, vimentin, and frataxin, as well as relevant receptors such as dopamine DA1R/DA2R.

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  • Accessories (34)
  • Consumables (2)
  • Reagents (147)
  • Software and Informatics (6)
Assay Target
  • Aβ1-40 (2)
  • Aβ1-42 (1)
  • Aβ1-x (1)
  • Aβ40 (3)
  • Aβ42 (1)
  • EPO (1)
  • Frataxin (2)
  • GAD67 (2)
  • NFL (1)
  • pNFH (1)
  • Tau (1)
  • TDP-43 (2)
Target Species
  • Human (16)
Application
  • cAMP (11)
  • Drug Discovery & Development (46)
  • Immunohistochemistry (IHC) (23)
  • In situ hybridization (ISH) (23)
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  • Protein Analysis & Detection (16)
Therapeutic Area
  • Angiogenesis (9)
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  • CNS & Neurologic (1)
  • Diabetes (10)
  • Gastrointestinal (31)
  • Inflammation (51)
  • Metabolic (30)
  • Obesity (1)
  • Pain (21)
Product Brand Name
  • AequoScreen (14)
  • AequoZen (12)
  • AlphaLISA (10)
  • Ancillary Products (2)
  • cAMPZen (7)
  • LANCE Ultra (8)
  • Membrane Target Systems (35)
  • NEN (2)
  • NEN Radiochemicals (1)
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
  • TSA (12)
  • TSA Plus (12)
  • ValiScreen (15)
Detection Method
  • Alpha (10)
  • Chromogenic (6)
  • Fluorescence (25)
  • Radiometric (3)
  • Time-Resolved Fluorescence (TRF) (8)
  • TR-FRET (8)
Receptor Type
  • 5-Hydroxytryptamine (Serotonin) (38)
  • Adrenergic (10)
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Assay Validated
  • Binding (72)
  • Calcium Fluorescence (16)
  • Calcium Luminescence (32)
  • cAMP (20)
  • Downstream Phosphorylation (5)
  • GTPγS (19)
  • Inositol Phosphate (3)
Radioisotope
  • H-3 (1)
  • S-35 (2)
Radionuclide
  • 35S (2)
  • 3H (1)
Volume Capacity
  • 150 μL (2)
Nucleotide
  • UTP (2)
Fluorophore
  • Coumarin (1)
  • Cy3 (8)
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  • Fluorescein (6)
  • TMR (5)
Label Position
  • alpha (2)
  • Nominally Labeled (1)
Buffer
  • Tricine (2)
Assay Points (200-50,000)
  • 100 (2)
  • 10000 (4)
  • 500 (13)
  • 5000 (9)
Assay Target Class
  • Cytokine (1)
  • GPCR (80)
  • Ion channel (3)
  • Peptide (7)
  • Protein (10)
Automation Compatible
  • Yes (18)
Concentration
  • 12.5 mCi/mL (1)
Experimental Type
  • In vitro (16)
Format
  • Microplates (16)
  • Slides (23)
Host Cell
  • 1321N1 (4)
  • CHO-K1 (65)
  • HEK293 (13)
  • L Cells (1)
  • UC11 (1)
Model Compatible With
  • Operetta (30)
  • Operetta CLS AND Opera Phenix (8)
Volume
  • 0-50 (1)

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